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Epidemiology and Mechanisms of Ceftazidime–Avibactam Resistance in Gram-Negative Bacteria Review

Tingting Xu, Yuqi Guo, Yang Ji, Baohong Wang, Kai Zhou

Engineering 2022, Volume 11, Issue 4,   Pages 138-145 doi: 10.1016/j.eng.2020.11.004

Abstract:

Carbapenem resistance presents a major challenge for the global public health network, as clinical infections caused by carbapenem-resistant organisms (CRO) are frequently associated with significant morbidity and mortality. Ceftazidime–avibactam (CAZ–AVI) is a novel cephalosporin/β-lactamase inhibitor combination offering an important advance in the treatment of CRO infections. CAZ–AVI has been reported to inhibit the activities of Ambler classes A, C, and some class D enzymes. However, bacterial resistance has been emerging shortly after the introduction of this combination in clinical use, with an increasing trend. Understanding these resistance mechanisms is crucial for guiding the development of novel treatments and aiding in the prediction of underlying resistance mechanisms. This review aims to systematically summarize the epidemiology of CAZ–AVI-resistant strains and recently identified resistance mechanisms of CAZ–AVI, with a focus on the production of β-lactamase variants, the hyperexpression of β-lactamases, reduced permeability, and overexpressed efflux pumps. The various mechanisms of CAZ–AVI resistance that have emerged within a short timescale emphasize the need to optimize the use of current agents, as well as the necessity for the surveillance of CAZ–AVI-resistant pathogens.

Keywords: Ceftazidime–avibactam     Resistance mechanism     Carbapenem-resistant     β-lactam/β-lactamase inhibitor    

Decitabine induces -mediated immune responses in p53-mutated triple-negative breast cancer: a clinical

Frontiers of Medicine doi: 10.1007/s11684-023-1016-8

Abstract: Here, we reposition decitabine for triple-negative breast cancer (TNBC), a subtype with frequent p53

Keywords: p53 mutation     triple-negative breast cancer     decitabine     DNMT1     IRF7     innate immune response    

The size distribution of airborne bacteria and human pathogenic bacteria in a commercial composting plant

Frontiers of Environmental Science & Engineering 2021, Volume 15, Issue 3, doi: 10.1007/s11783-020-1356-4

Abstract:

•Bacterial concentrations from eight stages were 104–105copies/m3.

Keywords: Size distribution     Airborne bacteria     Biological diversity     Human pathogenic bacteria     Composting plants    

Negative Energy in Faster Than Light Investigation ——An Important Direction to Researches

Huang Zhixun

Strategic Study of CAE 2001, Volume 3, Issue 7,   Pages 42-47

Abstract:

This paper describes a series of expectations and experiments on the negative energy notion.The aim is to find the relation between the faster-than-light research and the negative energy concepts

Keywords: negative energy     faster than light     Casimir's effect     evanescent mode     negative refraction index    

Progress in systemic therapy for triple-negative breast cancer

Hongnan Mo, Binghe Xu

Frontiers of Medicine 2021, Volume 15, Issue 1,   Pages 1-10 doi: 10.1007/s11684-020-0741-5

Abstract: Triple-negative breast cancer (TNBC) is the most aggressive subtype of breast cancer with a heterogeneous

Keywords: triple-negative breast cancer     immunotherapy     targeted therapy    

Electroactivity of the magnetotactic bacteria AMB-1 and MSR-1

Frontiers of Environmental Science & Engineering 2023, Volume 18, Issue 4, doi: 10.1007/s11783-024-1808-3

Abstract:

● The first study of electrochemically active magnetotactic bacteria

Keywords: Magnetotactic bacteria     Magnetospirillum magneticum     Magnetospirillum gryphiswaldense    

Automatic malware classification and new malwaredetection using machine learning Article

Liu LIU, Bao-sheng WANG, Bo YU, Qiu-xi ZHONG

Frontiers of Information Technology & Electronic Engineering 2017, Volume 18, Issue 9,   Pages 1336-1347 doi: 10.1631/FITEE.1601325

Abstract: The data processing module deals with gray-scale images,Opcode n-gram, and import functions, which are

Keywords: Malware classification     Machine learning     n-gram     Gray-scale image     Feature extraction     Malware detection    

Organic and inorganic phosphorus uptake by bacteria in a plug-flow microcosm

Jinbo ZHAO, Xuehua LIU

Frontiers of Environmental Science & Engineering 2013, Volume 7, Issue 2,   Pages 173-184 doi: 10.1007/s11783-013-0494-3

Abstract: the uptake of two organic phosphorus compounds (phytic acid and D-glucose-6-phosphate) by freshwater bacteriaexperiment showed that D-glucose-6-phosphate (labile) could be hydrolysed and utilized easily by the bacteriaThe results also suggested that bacteria might break down the C-P bonds to utilize the carbon.investigate the effect of varying the C:N:P ratio in the microcosm system to determine which nutrient limits bacteria

Keywords: organic phosphorus     bacteria     uptake    

Visible light induces bacteria to produce superoxide for manganese oxidation

Frontiers of Environmental Science & Engineering 2023, Volume 17, Issue 2, doi: 10.1007/s11783-023-1619-y

Abstract:

● Term of manganese-oxidizing microorganisms should be reconsidered.

Keywords: Mn(II) oxidation     Manganese-oxidizing bacteria     Reactive oxygen species     Mn(III/IV) oxides    

Synergistic degradation of pyrene and volatilization of arsenic by cocultures of bacteria and a fungus

Shuang LIU, Yanwei HOU, Guoxin SUN

Frontiers of Environmental Science & Engineering 2013, Volume 7, Issue 2,   Pages 191-199 doi: 10.1007/s11783-012-0470-3

Abstract: The combination of two bacteria ( sp. PY1 and sp. PY2) and a fungus ( sp.

Keywords: pyrene     arsenic     bioremediation     bacteria     fungus    

Field validation of UHPC layer in negative moment region of steel-concrete composite continuous girder

Minghong QIU; Xudong SHAO; Weiye HU; Yanping ZHU; Husam H. HUSSEIN; Yaobei HE; Qiongwei LIU

Frontiers of Structural and Civil Engineering 2022, Volume 16, Issue 6,   Pages 744-761 doi: 10.1007/s11709-022-0843-z

Abstract: Improving the cracking resistance of steel-normal concrete (NC) composite beams in the negative momentThis study proposed an innovative structural configuration for the negative bending moment region inIn order to investigate the feasibility and effectiveness of this new UHPC jointed structure in the negativefield investigation, strains on the surface of the concrete bridge deck, rebar, and steel beam in the negativedemonstrated that the new configuration with the UHPC layer provided an effective alternative for the negative

Keywords: field test     steel-concrete composite beam     continuous girder bridge     negative bending moment region    

Prognostic value of the 21-gene recurrence score in ER-positive, HER2-negative, node-positive breastcancer was similar in node-negative diseases: a single-center study of 800 patients

Jiayi Wu, Weiqi Gao, Xiaosong Chen, Chunxiao Fei, Lin Lin, Weiguo Chen, Ou Huang, Siji Zhu, Jianrong He, Yafen Li, Li Zhu, Kunwei Shen

Frontiers of Medicine 2021, Volume 15, Issue 4,   Pages 621-628 doi: 10.1007/s11684-020-0738-0

Abstract: Chinese patients with pN0-1, estrogen receptor-positive (ER ), human epidermal growth factor receptor 2-negative

Keywords: early breast cancer     21-gene assay     recurrence score     prognosis    

Nitrifying and denitrifying bacteria in aerobic granules formed in sequencing batch airlift reactors

WANG Fang, YANG Fenglin, QI Aijiu

Frontiers of Environmental Science & Engineering 2007, Volume 1, Issue 2,   Pages 184-189 doi: 10.1007/s11783-007-0032-2

Abstract: The purpose of this study was to investigate nitrifying bacteria and denitrifying bacteria isolated fromBacteria were isolated and determined from aerobic granules using selected media.The growth properties and morphology of bacteria colonies were observed by controlling aerobic or anaerobicIt was found that bacteria in aerobic granules were diverse and some of them were facultative aerobesThe diversity of bacteria in aerobic granules was a premise of simultaneous nitrification and denitrification

The Negative Electrostatic Spring Effect Analysis and Experimental Validation of Silicon Micromechanical

Xia Dunzhu,Zhou Bailing,Wang Shourong

Strategic Study of CAE 2007, Volume 9, Issue 8,   Pages 66-68

Abstract:  The negative electrostatic spring effect of feedback force generator is analyzed in focus,  

Keywords: silicon micromechanical z-axis gyroscope     negative electrostatic spring constant     feedback force generator    

Airborne bacteria associated with particulate matter from a highly urbanised metropolis: A potential

Frontiers of Environmental Science & Engineering 2022, Volume 16, Issue 9, doi: 10.1007/s11783-022-1552-5

Abstract:

• The airborne bacteria of Mexico City are representative of urban environments

Keywords: Airborne bacteria     Urbanisation     PM10     Mexico City     Microbiome    

Title Author Date Type Operation

Epidemiology and Mechanisms of Ceftazidime–Avibactam Resistance in Gram-Negative Bacteria

Tingting Xu, Yuqi Guo, Yang Ji, Baohong Wang, Kai Zhou

Journal Article

Decitabine induces -mediated immune responses in p53-mutated triple-negative breast cancer: a clinical

Journal Article

The size distribution of airborne bacteria and human pathogenic bacteria in a commercial composting plant

Journal Article

Negative Energy in Faster Than Light Investigation ——An Important Direction to Researches

Huang Zhixun

Journal Article

Progress in systemic therapy for triple-negative breast cancer

Hongnan Mo, Binghe Xu

Journal Article

Electroactivity of the magnetotactic bacteria AMB-1 and MSR-1

Journal Article

Automatic malware classification and new malwaredetection using machine learning

Liu LIU, Bao-sheng WANG, Bo YU, Qiu-xi ZHONG

Journal Article

Organic and inorganic phosphorus uptake by bacteria in a plug-flow microcosm

Jinbo ZHAO, Xuehua LIU

Journal Article

Visible light induces bacteria to produce superoxide for manganese oxidation

Journal Article

Synergistic degradation of pyrene and volatilization of arsenic by cocultures of bacteria and a fungus

Shuang LIU, Yanwei HOU, Guoxin SUN

Journal Article

Field validation of UHPC layer in negative moment region of steel-concrete composite continuous girder

Minghong QIU; Xudong SHAO; Weiye HU; Yanping ZHU; Husam H. HUSSEIN; Yaobei HE; Qiongwei LIU

Journal Article

Prognostic value of the 21-gene recurrence score in ER-positive, HER2-negative, node-positive breastcancer was similar in node-negative diseases: a single-center study of 800 patients

Jiayi Wu, Weiqi Gao, Xiaosong Chen, Chunxiao Fei, Lin Lin, Weiguo Chen, Ou Huang, Siji Zhu, Jianrong He, Yafen Li, Li Zhu, Kunwei Shen

Journal Article

Nitrifying and denitrifying bacteria in aerobic granules formed in sequencing batch airlift reactors

WANG Fang, YANG Fenglin, QI Aijiu

Journal Article

The Negative Electrostatic Spring Effect Analysis and Experimental Validation of Silicon Micromechanical

Xia Dunzhu,Zhou Bailing,Wang Shourong

Journal Article

Airborne bacteria associated with particulate matter from a highly urbanised metropolis: A potential

Journal Article