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Epidemiology and Mechanisms of Ceftazidime–Avibactam Resistance in Gram-Negative Bacteria Review
Tingting Xu, Yuqi Guo, Yang Ji, Baohong Wang, Kai Zhou
Engineering 2022, Volume 11, Issue 4, Pages 138-145 doi: 10.1016/j.eng.2020.11.004
Carbapenem resistance presents a major challenge for the global public health network, as clinical infections caused by carbapenem-resistant organisms (CRO) are frequently associated with significant morbidity and mortality. Ceftazidime–avibactam (CAZ–AVI) is a novel cephalosporin/β-lactamase inhibitor combination offering an important advance in the treatment of CRO infections. CAZ–AVI has been reported to inhibit the activities of Ambler classes A, C, and some class D enzymes. However, bacterial resistance has been emerging shortly after the introduction of this combination in clinical use, with an increasing trend. Understanding these resistance mechanisms is crucial for guiding the development of novel treatments and aiding in the prediction of underlying resistance mechanisms. This review aims to systematically summarize the epidemiology of CAZ–AVI-resistant strains and recently identified resistance mechanisms of CAZ–AVI, with a focus on the production of β-lactamase variants, the hyperexpression of β-lactamases, reduced permeability, and overexpressed efflux pumps. The various mechanisms of CAZ–AVI resistance that have emerged within a short timescale emphasize the need to optimize the use of current agents, as well as the necessity for the surveillance of CAZ–AVI-resistant pathogens.
Keywords: Ceftazidime–avibactam Resistance mechanism Carbapenem-resistant β-lactam/β-lactamase inhibitor
Frontiers of Medicine doi: 10.1007/s11684-023-1016-8
Keywords: p53 mutation triple-negative breast cancer decitabine DNMT1 IRF7 innate immune response
Frontiers of Environmental Science & Engineering 2021, Volume 15, Issue 3, doi: 10.1007/s11783-020-1356-4
•Bacterial concentrations from eight stages were 104–105copies/m3.
Keywords: Size distribution Airborne bacteria Biological diversity Human pathogenic bacteria Composting plants
Negative Energy in Faster Than Light Investigation ——An Important Direction to Researches
Huang Zhixun
Strategic Study of CAE 2001, Volume 3, Issue 7, Pages 42-47
This paper describes a series of expectations and experiments on the negative energy notion.The aim is to find the relation between the faster-than-light research and the negative energy concepts
Keywords: negative energy faster than light Casimir's effect evanescent mode negative refraction index
Progress in systemic therapy for triple-negative breast cancer
Hongnan Mo, Binghe Xu
Frontiers of Medicine 2021, Volume 15, Issue 1, Pages 1-10 doi: 10.1007/s11684-020-0741-5
Keywords: triple-negative breast cancer immunotherapy targeted therapy
Electroactivity of the magnetotactic bacteria AMB-1 and MSR-1
Frontiers of Environmental Science & Engineering 2023, Volume 18, Issue 4, doi: 10.1007/s11783-024-1808-3
● The first study of electrochemically active magnetotactic bacteria
Keywords: Magnetotactic bacteria Magnetospirillum magneticum Magnetospirillum gryphiswaldense
Automatic malware classification and new malwaredetection using machine learning Article
Liu LIU, Bao-sheng WANG, Bo YU, Qiu-xi ZHONG
Frontiers of Information Technology & Electronic Engineering 2017, Volume 18, Issue 9, Pages 1336-1347 doi: 10.1631/FITEE.1601325
Keywords: Malware classification Machine learning n-gram Gray-scale image Feature extraction Malware detection
Organic and inorganic phosphorus uptake by bacteria in a plug-flow microcosm
Jinbo ZHAO, Xuehua LIU
Frontiers of Environmental Science & Engineering 2013, Volume 7, Issue 2, Pages 173-184 doi: 10.1007/s11783-013-0494-3
Keywords: organic phosphorus bacteria uptake
Visible light induces bacteria to produce superoxide for manganese oxidation
Frontiers of Environmental Science & Engineering 2023, Volume 17, Issue 2, doi: 10.1007/s11783-023-1619-y
● Term of manganese-oxidizing microorganisms should be reconsidered.
Keywords: Mn(II) oxidation Manganese-oxidizing bacteria Reactive oxygen species Mn(III/IV) oxides
Shuang LIU, Yanwei HOU, Guoxin SUN
Frontiers of Environmental Science & Engineering 2013, Volume 7, Issue 2, Pages 191-199 doi: 10.1007/s11783-012-0470-3
Keywords: pyrene arsenic bioremediation bacteria fungus
Minghong QIU; Xudong SHAO; Weiye HU; Yanping ZHU; Husam H. HUSSEIN; Yaobei HE; Qiongwei LIU
Frontiers of Structural and Civil Engineering 2022, Volume 16, Issue 6, Pages 744-761 doi: 10.1007/s11709-022-0843-z
Keywords: field test steel-concrete composite beam continuous girder bridge negative bending moment region
Jiayi Wu, Weiqi Gao, Xiaosong Chen, Chunxiao Fei, Lin Lin, Weiguo Chen, Ou Huang, Siji Zhu, Jianrong He, Yafen Li, Li Zhu, Kunwei Shen
Frontiers of Medicine 2021, Volume 15, Issue 4, Pages 621-628 doi: 10.1007/s11684-020-0738-0
Keywords: early breast cancer 21-gene assay recurrence score prognosis
Nitrifying and denitrifying bacteria in aerobic granules formed in sequencing batch airlift reactors
WANG Fang, YANG Fenglin, QI Aijiu
Frontiers of Environmental Science & Engineering 2007, Volume 1, Issue 2, Pages 184-189 doi: 10.1007/s11783-007-0032-2
Xia Dunzhu,Zhou Bailing,Wang Shourong
Strategic Study of CAE 2007, Volume 9, Issue 8, Pages 66-68
Keywords: silicon micromechanical z-axis gyroscope negative electrostatic spring constant feedback force generator
Airborne bacteria associated with particulate matter from a highly urbanised metropolis: A potential
Frontiers of Environmental Science & Engineering 2022, Volume 16, Issue 9, doi: 10.1007/s11783-022-1552-5
• The airborne bacteria of Mexico City are representative of urban environments
Keywords: Airborne bacteria Urbanisation PM10 Mexico City Microbiome
Title Author Date Type Operation
Epidemiology and Mechanisms of Ceftazidime–Avibactam Resistance in Gram-Negative Bacteria
Tingting Xu, Yuqi Guo, Yang Ji, Baohong Wang, Kai Zhou
Journal Article
Decitabine induces -mediated immune responses in p53-mutated triple-negative breast cancer: a clinical
Journal Article
The size distribution of airborne bacteria and human pathogenic bacteria in a commercial composting plant
Journal Article
Negative Energy in Faster Than Light Investigation ——An Important Direction to Researches
Huang Zhixun
Journal Article
Progress in systemic therapy for triple-negative breast cancer
Hongnan Mo, Binghe Xu
Journal Article
Automatic malware classification and new malwaredetection using machine learning
Liu LIU, Bao-sheng WANG, Bo YU, Qiu-xi ZHONG
Journal Article
Organic and inorganic phosphorus uptake by bacteria in a plug-flow microcosm
Jinbo ZHAO, Xuehua LIU
Journal Article
Synergistic degradation of pyrene and volatilization of arsenic by cocultures of bacteria and a fungus
Shuang LIU, Yanwei HOU, Guoxin SUN
Journal Article
Field validation of UHPC layer in negative moment region of steel-concrete composite continuous girder
Minghong QIU; Xudong SHAO; Weiye HU; Yanping ZHU; Husam H. HUSSEIN; Yaobei HE; Qiongwei LIU
Journal Article
Prognostic value of the 21-gene recurrence score in ER-positive, HER2-negative, node-positive breastcancer was similar in node-negative diseases: a single-center study of 800 patients
Jiayi Wu, Weiqi Gao, Xiaosong Chen, Chunxiao Fei, Lin Lin, Weiguo Chen, Ou Huang, Siji Zhu, Jianrong He, Yafen Li, Li Zhu, Kunwei Shen
Journal Article
Nitrifying and denitrifying bacteria in aerobic granules formed in sequencing batch airlift reactors
WANG Fang, YANG Fenglin, QI Aijiu
Journal Article
The Negative Electrostatic Spring Effect Analysis and Experimental Validation of Silicon Micromechanical
Xia Dunzhu,Zhou Bailing,Wang Shourong
Journal Article